Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Causes of Social Behavior III: Biological and Environmental Influences01:28

Causes of Social Behavior III: Biological and Environmental Influences

Social behavior is a complex phenomenon that arises from the interaction between biological predispositions and environmental influences. This intricate interplay shapes how individuals think, feel, and act in various social contexts. Understanding these mechanisms requires insights from psychology, neuroscience, genetics, and evolutionary theory.Environmental Influences on Social BehaviorEnvironmental factors, including temperature, odors, and visual stimuli, play a crucial role in shaping...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gastrointestinal side effects associated with antidepressant treatments in patients with major depressive disorder: A systematic review and meta-analysis.

Progress in neuro-psychopharmacology & biological psychiatry·2021
Same author

Possible Modulatory Role of ARC Gene Variants in Mood Disorders.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2021
Same author

A Practical Utility and Benefit of Pharmacogenetic-based Antidepressant Treatment Strategy for Major Depressive Disorder Patients with Difficult-to-treat.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2021
Same author

Research Domain Criteria (RDoC): A Perspective to Probe the Biological Background behind Treatment Efficacy in Depression.

Current medicinal chemistry·2021
Same author

Cost-effectiveness of genetic and clinical predictors for choosing combined psychotherapy and pharmacotherapy in major depression.

Journal of affective disorders·2020
Same author

Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorder.

Progress in neuro-psychopharmacology & biological psychiatry·2020

Related Experiment Video

Updated: May 9, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
05:42

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

Gene environment interaction studies in depression and suicidal behavior: An update.

Laura Mandelli1, Alessandro Serretti

  • 1Psychiatry Section, Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy.

Neuroscience and Biobehavioral Reviews
|July 27, 2013
PubMed
Summary

Gene-environment interactions influence major depression and suicidal behavior risk. While some genes show effects, more research is needed to understand these complex gene-environment interactions in mental health.

Keywords:
ABCG1ACEAPOEATP-binding cassette subfamily G member 1AVPR1BBDNFCNR1COMTCRHCRHBPCRHR1CRHR2DBHDRD1DRD2DRD3DRD4DRD5EnvironmentFK506-binding protein 5FKBP5FMR1GABRA1GABRA2GABRA5GABRG1GABRG2GAD1gGLULgGPX1GRIA1gGRIN2AgGRIN2BgGRIN2CGRIN2DGRIN3AGRIN3BGRM7GSK3BGeneticsGene×environment interactionG×EHTR1AHTR1BHTR2AHTR2CHTR3AIL10IL18MAOAMDMajor depressionNPYNR3C1NTRK2ODC1OXTRRGS2SBSLC6A2SLC6A3SLC6A4SLEsStressful life eventsSuicideTNFTPH1TPH2angiotensin-converting enzymeapoliprotein Eargivanine vasopressin receptor 1Bbrain-derived neurotrophic factorcannabinoid receptor 1catechol-O-methyltransferase Acorticotrophin-releasing hormonecorticotrophin-releasing hormone binding proteincorticotrophin-releasing hormone receptor 1corticotrophin-releasing hormone receptor 2dopamine beta-hydroxylasedopamine receptor D1dopamine receptor D2dopamine receptor D3dopamine receptor D4fragile-X mental retardation proteingamma-aminobutyric acid receptor alpha1gamma-aminobutyric acid receptor alpha2gamma-aminobutyric acid receptor alpha5gamma-aminobutyric acid receptor gamma1gamma-aminobutyric acid receptor gamma2gene–environment interactionglutamate receptor ionotropic 2C (glutamate receptor 2C)glutamate receptor ionotropic 2D (glutamate receptor 2D)glutamate receptor ionotropic 3A (glutamate receptor 3A)glutamate receptor ionotropic 3B (glutamate receptor 3B)glutamate receptor metabotropic 7glutathione peroxidaseglycogen-synthase 3betainterleukin 10interleukin 18lutamate decarboxylase 1lutamate receptor ionotropic 2A (glutamate receptor 2A)lutamate receptor ionotropic 2B (glutamate receptor 2B)lutamate receptor ionotropic AMPA 1 (glutamate receptor 1)lutamate-ammonia ligase (glutamine synthase)major depressionmonoamine-oxidase Aneuronal tryptophan hydroxylaseneuropeptide Yneurotrophic tyrosine kinase receptor 2nuclear receptor sub family 3 group c member 1 (glucocorticoid receptor)ornithine decarboxylase 1oxytocin receptorregulator of G-protein signaling 2serotonin receptor 1Aserotonin receptor 2Aserotonin receptor 2Bserotonin receptor 2Cserotonin receptor 3Asolute carrier 6 A2 (noradrenalin transportersolute carrier 6 A3 (dopamine transporter)solute carriers 6A (serotonin transporter)stressful life eventssuicidal behaviortryptophan hydroxylasetumor necrosis factor

More Related Videos

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Animal Models of Depression - Chronic Despair Model (CDM)
05:47

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

Related Experiment Videos

Last Updated: May 9, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
05:42

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Animal Models of Depression - Chronic Despair Model (CDM)
05:47

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

Area of Science:

  • Psychiatry
  • Genetics
  • Environmental Health

Background:

  • Major depression (MD) and suicidal behavior (SB) are influenced by both genetic and environmental factors.
  • Gene-environment interaction (G × E) studies are crucial for understanding the biological mechanisms underlying mental disorders.

Purpose of the Study:

  • To review existing literature on G × E in the etiology of MD and SB.
  • To discuss the added value of G × E studies compared to genetic studies alone.
  • To highlight limitations and suggest future research directions.

Main Methods:

  • Literature review of studies investigating gene-environment interactions in major depression and suicidal behavior.
  • Analysis of findings concerning specific genes and environmental risk factors.
  • Discussion of methodological challenges in G × E research.

Main Results:

  • Few reliable G × E results have been obtained to date.
  • Some genes have consistently demonstrated interactive effects with environmental risks in MD and SB.
  • Further research is needed to differentiate direct and mediated effects common or specific to MD and SB.

Conclusions:

  • G × E research is essential for understanding the complex interplay of factors contributing to MD and SB.
  • Current G × E studies face methodological limitations.
  • Novel interdisciplinary methodological strategies are required for advancing G × E research in mental health.