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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Updated: May 9, 2026

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos
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Long non-coding RNAs in haematological malignancies.

Andoni Garitano-Trojaola1, Xabier Agirre, Felipe Prósper

  • 1Laboratory of Myeloproliferative Syndromes, Oncology Area, Foundation for Applied Medical Research, University of Navarra, Pamplona 31008, Spain. agaritano@alumni.unav.es

International Journal of Molecular Sciences
|July 27, 2013
PubMed
Summary

Long non-coding RNAs (lncRNAs) regulate gene expression and cellular functions. Dysregulation of lncRNAs plays a key role in blood cancers, offering potential for diagnosis and therapy.

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Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Long non-coding RNAs (lncRNAs) are RNA molecules exceeding 200 nucleotides with low coding potential.
  • lncRNAs are primarily nuclear, tissue-specific, and regulate gene expression through various mechanisms.
  • They are implicated in cell differentiation, growth, and have roles in oncogenesis and tumor suppression.

Purpose of the Study:

  • To review the current understanding of lncRNAs.
  • To explore lncRNA regulation mechanisms in cancer.
  • To discuss the role of lncRNAs in hematological malignancies and their therapeutic potential.

Main Methods:

  • Literature review of lncRNA functions and roles in cancer.
  • Analysis of lncRNA regulatory mechanisms in gene expression.
  • Focus on lncRNAs in leukemogenesis, lymphomagenesis, and hematopoiesis.

Main Results:

  • lncRNAs modulate gene expression by guiding chromatin remodelers, affecting transcription, and serving as scaffolds.
  • Many lncRNAs exhibit oncogenic or tumor suppressor activities in various cancers.
  • lncRNAs are crucial in hematopoiesis and hematological malignancies.

Conclusions:

  • lncRNAs are essential regulators of cellular processes and play significant roles in blood cancers.
  • Understanding lncRNA regulation in cancer is vital for developing novel diagnostic and therapeutic strategies.
  • lncRNAs hold promise as biomarkers and therapeutic targets in hematological malignancies.