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Common acquired causes of thrombosis in children

Jaszianne Tolbert1, Shannon L Carpenter

  • 1Division of Pediatric Hematology/Oncology/BMT, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.

Current Problems in Pediatric and Adolescent Health Care
|July 30, 2013
PubMed

Insights

Pediatric venous thromboembolism is rare but serious. Risk factors include cancer and cardiac disease, yet acquired thrombophilia studies and optimal treatments for children are limited, often relying on adult data.

Area of Science:

  • Pediatric Hematology
  • Pediatric Thrombosis
  • Medical Literature Review

Background:

  • Venous thromboembolism (VTE) is uncommon in children compared to adults.
  • Established risk factors for pediatric VTE include cancer, cardiac disease, antiphospholipid antibodies, and indwelling catheters.
  • Limited research exists on acquired thrombophilia in pediatric populations.

Purpose of the Study:

  • To review the existing literature on thrombophilia in children.
  • To explore the relationship between childhood cancer, cardiac disease, antiphospholipid antibody syndrome, and thrombosis.
  • To identify gaps in knowledge regarding pediatric VTE.

Main Methods:

  • Comprehensive literature search of studies on pediatric thrombophilia.
  • Review of articles focusing on childhood cancer and thrombosis.
  • Examination of research on cardiac disease and thrombosis in children.
  • Analysis of studies concerning antiphospholipid antibody syndrome in pediatric patients.
  • Citation mining to identify additional relevant articles.

Main Results:

  • Studies investigating acquired thrombophilia in children are notably limited.
  • Current treatment protocols for pediatric VTE are primarily extrapolated from adult data.
  • Optimal therapeutic strategies for VTE in children remain undetermined.

Conclusions:

  • There is a significant need for more research into acquired thrombophilia in children.
  • Evidence-based guidelines for managing VTE in pediatric populations are lacking.
  • Further investigation is required to establish effective and specific treatments for pediatric venous thromboembolism.

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