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Mitral Valve Prolapse III: Nursing Management

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Updated: May 9, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

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Published on: January 26, 2024

Vascular dysfunction in preeclampsia.

Lesley J Brennan1, Jude S Morton, Sandra T Davidge

  • 1Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, Alberta, Canada; Women and Children's Health Research Institute and the Cardiovascular Research Centre, Edmonton, Alberta, Canada.

Microcirculation (New York, N.Y. : 1994)
|July 30, 2013
PubMed
Summary
This summary is machine-generated.

Preeclampsia, a pregnancy disorder affecting 5% globally, causes hypertension and proteinuria. This review explores its links to placental issues and maternal vascular dysfunction, impacting cardiovascular health.

Keywords:
circulating factorsendothelial dysfunctionplacental ischemiapreeclampsia

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Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Medicine
  • Reproductive Biology

Background:

  • Preeclampsia affects 5% of pregnancies globally, characterized by hypertension and proteinuria after 20 weeks.
  • It is a leading cause of maternal morbidity, mortality, and iatrogenic preterm delivery.
  • The disorder is linked to maternal vascular dysfunction and significant cardiovascular risk.

Purpose of the Study:

  • This review aims to discuss the mechanisms of action and consequences of preeclampsia on maternal vasculature.
  • It will explore the role of placental ischemia and aberrant placentation in the disorder's pathogenesis.
  • The review will examine how released factors impact endothelial function and oxidative stress.

Main Methods:

  • Literature review of existing research on preeclampsia.
  • Analysis of factors involved in placental development and maternal vascular response.
  • Synthesis of information on endothelial dysfunction and oxidative stress in preeclampsia.

Main Results:

  • Preeclampsia is fundamentally characterized by placental ischemia due to aberrant placentation.
  • Aberrant placentation triggers the release of pro- and antiangiogenic factors and inflammatory mediators.
  • These factors critically mediate maternal vascular function, leading to endothelial dysfunction and oxidative stress.

Conclusions:

  • Preeclampsia involves complex interactions between placental factors and maternal vascular health.
  • Endothelial dysfunction is a key component of the maternal syndrome, increasing cardiovascular risk.
  • Understanding these mechanisms is crucial for managing preeclampsia and its long-term consequences.