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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Published on: May 17, 2024

Paraneoplastic neuropathies.

Francesc Graus1, Josep Dalmau

  • 1Service of Neurology, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. fgraus@clinic.ub.es

Current Opinion in Neurology
|July 30, 2013
PubMed
Summary
This summary is machine-generated.

Advances in paraneoplastic neuropathies are reviewed, focusing on specific syndromes and novel therapies. Clinical and neurophysiological studies aid in accurate identification of these complex neurological conditions.

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Area of Science:

  • Neurology
  • Oncology
  • Immunology

Background:

  • Paraneoplastic neuropathies are rare neurological disorders associated with cancer.
  • Early and accurate diagnosis is crucial for effective management and improved patient outcomes.

Purpose of the Study:

  • To review recent advances in paraneoplastic neuropathies.
  • To highlight specific syndromes and the impact of emerging therapies.

Main Methods:

  • Literature review of relevant studies on paraneoplastic neuropathies.
  • Analysis of clinical and neurophysiological findings.
  • Evaluation of treatment outcomes for novel therapies.

Main Results:

  • Sensory neuronopathy may present insidiously, often in older males with subacute onset, pain, and arm involvement.
  • Paraneoplastic sensorimotor polyneuropathies can mimic CIDP or neurolymphomatosis.
  • POEMS syndrome neuropathy shows distinct neurophysiological features differentiating it from CIDP.
  • Waldenström macroglobulinemia neuropathy is heterogeneous, with demyelinating or axonal features.
  • Combination therapies like cyclophosphamide and rituximab show promise for paraneoplastic neuronopathies.
  • Lenalidomide and dexamethasone are effective for POEMS syndrome neuropathy.

Conclusions:

  • Clinical and neurophysiological studies are essential for precise identification of paraneoplastic neuropathies.
  • New therapeutic strategies offer improved management options for affected patients.