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In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
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Published on: March 30, 2015

A clear picture of renal cell carcinoma

A Ari Hakimi, Can G Pham, James J Hsieh

    Nature Genetics
    |July 30, 2013
    PubMed

    Insights

    Two large studies reveal similar molecular profiles in clear-cell renal cell carcinoma (ccRCC). These findings offer new therapeutic strategies for this treatment-resistant kidney cancer.

    Area of Science:

    • Oncology
    • Genomics
    • Molecular Biology

    Background:

    • Clear-cell renal cell carcinoma (ccRCC) is a significant subtype of kidney cancer.
    • Current treatments for ccRCC often face challenges due to resistance to chemotherapy and radiation.

    Discussion:

    • Two recent, large-scale molecular profiling studies of ccRCC have been published.
    • These independent analyses yielded remarkably consistent findings regarding recurrent pathway alterations.

    Key Insights:

    • The studies identified shared molecular pathways that are frequently altered in ccRCC.
    • These recurrent alterations are crucial for understanding ccRCC pathogenesis.

    Outlook:

    • The identified pathway alterations present novel therapeutic targets.
    • This research paves the way for developing new treatment strategies for ccRCC.
    • Further investigation into these targets may overcome resistance to current therapies.

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