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Updated: May 9, 2026
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
Prognostic value of lymphovascular space invasion in endometrial cancer
Mario Puljiz1, Željko Puljiz, Damir Danolić
11Department of Gynecologic Oncology, Sestre Milosrdnice University Hospital Centre-University Hospital for Tumors, Zagreb, 2Department of Gastroenterology, University Hospital Centre Split, Split, 3Department of Transfusion Medicine, 4Department of Clinical Pathology, 5Department for Internistic Oncology and Chemotherapy; Sestre Milosrdnice University Hospital Centre-University Hospital for Tumors, Zagreb; Croatia.
Aim:
To evaluate the prognostic significance of lymphovascular space invasion (LVSI) in endometrial cancer (EC) patients.
Methods:
A total of 73 patients who underwent surgery for endometrial cancer at the University Hospital for Tumors, Zagreb, Croatia and University Hospital Centre Split, Croatia, in the period from 1999 to 2008 were evaluated.
Results:
Lymphovascular space invasion was identified in 58 cases (79.5%). Univariate analysis and multivariate analysis demonstrated a significant association between LVSI and EC recurrence (p=0.004; HR 0.241, CI 0.114-0.511). The median time from diagnosis to EC recurrence of patients with positive LVSI was 20 months, and the median time from diagnosis to EC recurrence of patients with negative LVSI was 86 months (relative risk of recurrence 0.24).
Conclusion:
Lymphovascular space invasion identified on routine haematoxylin and eosin stained sections, is a significant independent predictor of endometrial cancer recurrence.
