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[The antioxidant status of children with congenital cleft lip and (or) palate]
Insights
Children with cleft lip/palate and their parents show increased lipid peroxidation (LPO). A subgroup of children with high LPO and low antioxidant activity may face more complications, needing antioxidant therapy.
Area of Science:
- Biochemistry
- Pediatric Medicine
- Genetics
Background:
- Cleft lip and/or palate (CLP) are common congenital anomalies.
- Lipid peroxidation (LPO) is a marker of oxidative stress.
- Endogenous antioxidant systems play a crucial role in cellular protection.
Purpose of the Study:
- To investigate lipid peroxidation (LPO) parameters and antioxidant status in children with CLP and their parents.
- To identify potential risk factors for postoperative complications in children with CLP.
Main Methods:
- Assessed Schiff's bases and diene conjugates (DC) as LPO markers.
- Measured blood serum alpha-tocopherol as an indicator of antioxidant status.
- Included 22 children with CLP and their parents in the study.
Main Results:
- Intensified LPO processes were observed in both children with CLP and their parents.
- Significantly elevated DC levels (p < 0.001) were found in 18 out of 22 children.
- A subgroup of children exhibited high LPO with reduced endogenous antioxidant activity.
Conclusions:
- Elevated LPO and reduced antioxidant activity in children with CLP indicate increased oxidative stress.
- This subgroup represents a potential risk group for postoperative complications.
- Preoperative antioxidant correcting therapy is recommended for children at risk.
Abstract:
Lipid peroxidation (LPO) parameters, Schiff's bases and diene conjugates (DC), as well as endogenous antioxidant system parameters, blood serum alpha-tocopherol were examined in 22 children with cleft lips and/or palates and their parents. DC LPO processes were found intensified in both children and their parents. Various DC levels were detected in probands: normal in 4 and significantly elevated (p less than 0.001) in 18 children. A group of children with intensified LPO processes and a reduced level of endogenous antioxidant activity was distinguished, that appears to be a risk group in respect of postoperative complications and therefore is in need of adequate preoperative antioxidant correcting therapy.