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Relationship between oxidative stress parameters and cystatin C levels in patients with severe preeclampsia
Saban Yalcin1, Turgay Ulas, Mehmet Ali Eren
1Department of Anesthesiology and Reanimation, Faculty of Medicine, Harran University, Turkey.
Insights
Severe preeclampsia (PE) is linked to increased oxidative stress and higher cystatin C levels. This study found that elevated cystatin C in PE patients may result from this oxidative stress.
Area of Science:
- Obstetrics and Gynecology
- Biochemistry
- Pathophysiology
Background:
- Oxidative stress is implicated in preeclampsia (PE) development.
- Elevated cystatin C levels are also associated with PE.
- The relationship between oxidative stress and cystatin C in severe PE requires further investigation.
Purpose of the Study:
- To investigate the association between oxidative stress markers and cystatin C levels in patients with severe PE.
- To compare these markers between severe PE patients and healthy pregnant women.
Main Methods:
- A case-control study involving 44 patients with severe PE and 40 healthy pregnant controls.
- Measurement of serum cystatin C, total antioxidant status (TAS), and total oxidant status (TOS).
- Calculation of the oxidative stress index (OSI).
Main Results:
- Severe PE patients exhibited significantly higher cystatin C, TOS, and OSI levels compared to controls.
- Total antioxidant status (TAS) was significantly lower in the severe PE group.
- Serum cystatin C levels showed a significant positive correlation with the oxidative stress index (OSI).
Conclusions:
- Both oxidative stress and cystatin C levels are elevated in patients with severe PE.
- Increased cystatin C levels in severe PE may be a consequence of heightened oxidative stress.
- Cystatin C may serve as a potential biomarker related to oxidative stress in PE.
Background And Objective:
Oxidative stress is believed to play a role in the development of preeclampsia (PE). It is known that an increased cystatin C level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and cystatin C levels in patients with severe PE.
Material And Methods:
Forty-four patients with severe PE and 40 healthy pregnant women were recruited for the study. All study subjects were divided into 2 groups: group 1 (n=44) consisted of patients with severe PE, and group 2 (n=40) included healthy pregnant subjects. Blood samples were obtained from all subjects in order to measure the cystatin C level, total antioxidant status, and total oxidant status. The oxidative stress index was calculated.
Results:
The group 1 had significantly higher cystatin C, total oxidant status, oxidative stress index levels and lower total antioxidant status level as compared with the group 2 (P=0.001, P<0.001, P<0.001, P=0.036, respectively). The serum cystatin C level was significantly correlated with the oxidative stress index (r=0.609, P<0.001).
Conclusions:
The present study demonstrated that both oxidative stress and cystatin C levels were increased in patients with PE, and the increased cystatin C levels seem to be a consequence of oxidative stress.
