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Related Concept Videos

Three-Dimensional Analysis of Strain01:29

Three-Dimensional Analysis of Strain

Three-dimensional strain analysis is crucial for understanding how materials deform under stress, particularly in elastic, homogeneous materials. This method employs principal stress axes to simplify complex stress states into more understandable forms. Subjected to stress, a small cubic element within a material either expands or contracts along these axes, transforming into a rectangular parallelepiped. This transformation effectively illustrates the material's deformation. The principal...
Measurements of Strain01:27

Measurements of Strain

Strain quantifies the deformation of a material under force, typically measured as normal strain, which represents the change in length when compared with the original length. Electrical strain gauges are used for enhanced accuracy. These devices consist of a conductive wire mounted on a paper backing that adheres to the material's surface. These gauges operate on the piezoresistive effect, where the wire's electrical resistance changes in response to mechanical deformation. The strain gauge...
Transformation of Plane Strain01:12

Transformation of Plane Strain

When analyzing elongated structures like bars subjected to uniformly distributed loads, it is essential to understand the transformation of plane strain when coordinate axes are rotated. This transformation helps to assess how material deformation characteristics vary with orientation, which is crucial in materials science and structural engineering.
Under plane strain conditions, typical for members where one dimension significantly exceeds the others, deformations and resultant strains are...
Stress-Strain Diagram01:10

Stress-Strain Diagram

A stress-strain diagram is a crucial tool that graphically displays a material's mechanical characteristics. This diagram is derived from a tensile test performed on a carefully prepared cylindrical specimen. The specimen has two gauge marks inscribed on its central part, and the distance between these marks is known as the gauge length. The cylindrical specimen is placed in a testing machine, which applies an increasing centric load. As this load grows, so does the gauge length. This change in...
True Stress and True Strain01:28

True Stress and True Strain

Engineering stress is calculated as the load divided by the original, undeformed cross-sectional area. It approximates a material under load. This approximation is especially relevant post-yield in ductile materials. Though engineering stress-strain diagrams are often used for their convenience and accessibility, they can sometimes fall short in accuracy, particularly when dealing with large strain values.
In contrast, true stress offers a more precise portrayal. It is computed by dividing the...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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Related Experiment Video

Updated: May 9, 2026

Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation
07:50

Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation

Published on: January 27, 2023

Nerve strain correlates with structural changes quantified by Fourier analysis.

James M Love1, Ting-Hsien Chuang, Richard L Lieber

  • 1Fischell Department of Bioengineering, University of Maryland, College Park, Maryland, USA.

Muscle & Nerve
|July 30, 2013
PubMed
Summary
This summary is machine-generated.

Bands of Fontana, a sign of nerve deformation, accurately indicate nerve strain. This automated method quantifies axonal undulations, improving understanding of neural structure-function relationships.

Keywords:
biomechanicshistologyimage processingperipheral nervestrain

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Image Analysis

Background:

  • Nerve deformation impacts physiological function.
  • Bands of Fontana are optical indicators of axonal undulations.
  • These bands may signal nerve strain.

Purpose of the Study:

  • To develop an automated method for quantifying Bands of Fontana periodicity.
  • To correlate Bands of Fontana with nerve strain and axonal waviness.

Main Methods:

  • Developed an automated Fourier-based image processing technique.
  • Quantified Bands of Fontana in bright field and immunolabeled images.
  • Analyzed longitudinal sections of rat sciatic nerves.

Main Results:

  • Found a strong linear relationship between applied strain and Bands of Fontana frequency (r2 = 0.829, P < 0.05).
  • Results align with strain-induced axonal waviness observed in myelin basic protein-labeled sections.

Conclusions:

  • An accurate, objective method for quantifying nerve strain was developed.
  • This approach enhances understanding of neural structure-function relationships.
  • Potential to guide neural function preservation and enhancement.