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Detecting intracellular cysteine redox states by in-cell NMR spectroscopy
Robert Silvers1, Harald Schwalbe
1Institute for Organic Chemistry and Chemical Biology, Center of Biomolecular Magnetic Resonance, Goethe University Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany).
Abstract:
An in-cell perspective: Nowadays, in-cell NMR spectroscopy has proven to be a thrilling alternative for the investigation of biomacromolecules under physiological conditions at atomic resolution. A recent example demonstrating significant progress in in-cell NMR was published by the groups of Banci and Aricescu that investigated the post-translational maturation of human superoxide dismutase 1 (SOD1) in living human cells.
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