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Updated: May 9, 2026
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Genome-wide association study on differentiated thyroid cancer.
Aleksandra Köhler1, Bowang Chen, Federica Gemignani
1PhD, Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. a.foersti@dkfz-heidelberg.de.
The Journal of Clinical Endocrinology and Metabolism
|July 30, 2013
Summary
This study identified new genetic markers associated with differentiated thyroid cancer (DTC) risk. These findings enhance our understanding of inherited factors contributing to DTC development.
Area of Science:
- Genetics
- Oncology
- Epidemiology
Background:
- Genome-wide association studies (GWAS) have identified several genetic loci associated with differentiated thyroid cancer (DTC).
- However, a significant portion of the inherited genetic risk factors for DTC remains undiscovered.
Purpose of the Study:
- To identify additional common genetic susceptibility loci for differentiated thyroid cancer.
- To expand the understanding of the genetic basis of DTC.
Main Methods:
- A genome-wide association study (GWAS) was conducted in a high-incidence Italian population.
- Significant polymorphisms were further validated in additional Italian and low-incidence populations.
Main Results:
- A strong association was confirmed for rs6759952 in DIRC3.
- Suggestive associations were identified with rs10238549 and rs7800391 in IMMP2L, rs7617304 in RARRES1, and rs10781500 in SNAPC4/CARD9.
Conclusions:
- The study provides new insights into the genetic and biological underpinnings of inherited susceptibility to DTC.
- Further research is required to elucidate the role of these identified polymorphisms in DTC development and their potential clinical applications.
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