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IL-21 in cancer immunotherapy: At the right place at the right time

Saskia Jam Santegoets1, Annelies W Turksma, Daniel J Powell

  • 1Department of Medical Oncology; VU University Medical Center; Cancer Center Amsterdam; Amsterdam, the Netherlands.

Oncoimmunology
|July 30, 2013
PubMed

Interleukin-21 (IL-21) has been described as a potent stimulator of antitumor T-cell immunity, but also of autoimmune reactions and oncogenesis. Antigen presenting cells genetically modified to release IL-21 allow for the expansion of tumor-specific T cells exhibiting favorable effector and growth characteristics and a minimal risk of detrimental side effects.

Keywords:
DC vaccinationIL-21adoptive cell transferantigen presenting cellcommon gamma-chain cytokine receptor family

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