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Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

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Related Experiment Video

Updated: May 9, 2026

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat
12:09

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat

Published on: April 18, 2020

Major peripheral nerve injuries.

Jonathan Isaacs1

  • 1Division of Hand Surgery, Department of Orthopaedic Surgery, Virginia Commonwealth University Health System, 1200 East Broad Street, PO Box 980153, Richmond, VA 23298, USA. jisaacs@mcvh-vcu.edu

Hand Clinics
|July 31, 2013
PubMed
Summary
This summary is machine-generated.

Major peripheral nerve injuries in upper extremities cause significant disability. Proper repair techniques, including grafts for larger gaps, improve outcomes, though prognosis remains guarded.

Keywords:
Major peripheral nervesNerve allograftNerve injuryNeurorrhaphy

Related Experiment Videos

Last Updated: May 9, 2026

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat
12:09

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat

Published on: April 18, 2020

Area of Science:

  • Orthopedics
  • Neurosurgery
  • Regenerative Medicine

Background:

  • Peripheral nerve injuries in the upper extremities lead to considerable morbidity.
  • Understanding injury pathophysiology is crucial for effective treatment planning.
  • Limited nerve mobilization often allows for tension-free repairs.

Purpose of the Study:

  • To review the principles and techniques for managing major peripheral nerve injuries in the upper extremities.
  • To discuss various nerve repair and reconstruction methods.
  • To highlight factors influencing patient prognosis.

Main Methods:

  • Review of current literature on peripheral nerve injury management.
  • Discussion of surgical techniques including suturing, nerve connectors, and biological conduits.
  • Analysis of reconstructive options such as autografts and allografts.

Main Results:

  • Tension-free repairs using sutures, fibrin glue, or connectors are feasible for injuries with limited nerve mobilization.
  • Acellular allografts and autografts are effective for bridging nerve gaps exceeding a few millimeters.
  • Adherence to established nerve repair principles enhances the likelihood of a favorable outcome.

Conclusions:

  • Optimal management of peripheral nerve injuries involves understanding pathophysiology and employing appropriate repair strategies.
  • Grafting techniques are essential for reconstructing larger nerve defects.
  • Despite advancements, peripheral nerve injuries in the upper extremities generally carry a guarded prognosis.