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Related Experiment Video

Updated: Jun 22, 2026

Murine Flexor Tendon Injury and Repair Surgery

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

Digital Nerve Repair With Flexor Tendon Injury: Conduits are Less Effective.

Jonathan Isaacs¹, Sanju Eswaran¹, Asif Ilyas²

¹Virginia Commonwealth University Medical Center, Richmond, USA.

Hand (New York, N.Y.)

|December 31, 2025

Summary

This summary is machine-generated.

Early mobilization after digital nerve repair with conduits, alongside flexor tendon repair, may hinder nerve regeneration. Processed nerve allograft (PNA) showed comparable outcomes to conduits in patients with concurrent tendon injuries.

Keywords:

conduits digital nerves nerve graft nerve repair processed acellular nerve allograft

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Area of Science:

Orthopedic Surgery
Neurosurgery
Regenerative Medicine

Background:

Digital nerve injuries often require reconstruction with conduits or processed nerve allograft (PNA) for gap defects.
Concurrent flexor tendon repair necessitates early mobilization, but its impact on nerve regeneration is unknown.

Purpose of the Study:

To evaluate the effect of concurrent flexor tendon repair and early mobilization on digital nerve regeneration outcomes.
To compare the efficacy of PNA versus conduits in digital nerve reconstruction with concomitant tendon injuries.

Main Methods:

A prospective, multi-center trial (RECON study) analyzed data from 182 patients undergoing digital nerve reconstruction.
Outcomes measured included static 2-point discrimination (S2PD) and Semmes-Weinstein Monofilament testing.
Comparisons were made based on reconstruction type (PNA vs. conduits) and the presence of concurrent flexor tendon repair.

Main Results:

In patients with tendon repair, S2PD was 6.8 mm for PNA and 8.1 mm for conduits.
Conduit repairs showed a significantly lower rate of achieving "normal" or "fair" American Society for Surgery of the Hand classifications in patients with tendon injuries (50%) compared to those without (73.3%).

Conclusions:

Concurrent flexor tendon repair with early mobilization may negatively impact conduit efficacy in digital nerve gap reconstruction.
Processed nerve allograft (PNA) demonstrated comparable functional outcomes to conduits in patients with combined nerve and tendon injuries.