[Abnormal expressions of positive cell cycle control factors and thyroid carcinoma occurrence and progression]

Lin Shi1, Anwen Zhang, Yu Luo

  • 1Department of Pathology, Medical College of Guangxi University of Science and Technology, Liuzhou, China. shilin19811120@163.com

Abstract

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...