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Matrix metalloproteinase7 -181A/G polymorphism is associated with increased cancer risk among high-quality studies:
Jing Wu1, Xuan Guan, Ya-Ting Li
1Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
Objectives:
To evaluate the effect of Matrix metalloproteinase 7 -181A/G polymorphism (rs11568818) on the risk of cancer, we performed a meta-analysis.
Design And Methods:
24 case-control studies were identified by searching Pubmed, Embase, ISI, OVID MEDLINE and EBSCO databases. Odd ratios and corresponding 95% confidence intervals were applied to assess the strength of association between MMP7 -181A/G polymorphism and cancer risk.
Results:
Between MMP7 -181GG genotype and cancer risk, statistically significant association could be observed from overall cancer risk, evidently noted in Asians, observed in high-quality subgroup, and apparently witnessed in PCR-RFLP genotyping subgroup.
Conclusions:
Our meta-analysis indicates that MMP7 -181GG genotype is associated with overall cancer risk in Asian populations (especially China and India) among high-quality studies.
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