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Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential

Matshawandile Tukulula1, Mathew Njoroge, Grace C Mugumbate

  • 1Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.

Bioorganic & Medicinal Chemistry
|July 31, 2013
PubMed

Keywords:
ADMEAntiplasmodialCytochrome P450DeoxyamodiaquineHPLCHigh pressure liquid chromatographyLC–MSLORALiquid chromatography mass spectrometryLow Oxygen Recovery AssayMABAMicroplate Alamar Blue AssayMulti-component reactionPharmacokineticsTMSN(3)absorption distribution metabolism excretiontrimethylsilyl azide

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