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A Catheter-Related Candida albicans Infection Model in Mouse
Published on: March 22, 2024
[Candida albicans endocarditis after treatment of complete atrioventricular canal]
S El Alami1, N Handor, Y Moutaki Allah
1Service de parasitologie mycologie, hôpital militaire d'instruction Mohammed V, Rabat, Morocco.
Insights
This case report highlights a rare pediatric fungal endocarditis caused by Candida albicans following atrioventricular canal surgery. Early diagnosis and optimized treatment are crucial for improving outcomes in this severe infection.
Area of Science:
- Pediatric Cardiology
- Infectious Diseases
- Cardiovascular Surgery
Background:
- Infective endocarditis is uncommon in children, particularly after atrioventricular canal repair.
- Candida albicans is an exceptional cause of endocarditis in this pediatric population.
Observation:
- A case of Candida albicans infective endocarditis is presented in a child with trisomy 21 post-atrioventricular canal repair.
- Diagnosis was aided by clinical signs, cardiac auscultation, positive blood cultures, and echocardiography revealing large vegetations.
Findings:
- The study confirms Candida albicans as a rare but serious etiologic agent in pediatric infective endocarditis.
- Large vegetations on echocardiography suggested a fungal origin, confirmed by blood cultures.
Implications:
- This case underscores the potential for fungal endocarditis as a complication of congenital heart defect surgery.
- Prompt diagnosis and tailored therapeutic strategies are essential for managing this high-mortality condition.
Abstract:
Infective endocarditis is rare in children, it is rarer after a surgical treatment of atrioventricular canal, and it is exceptional that Candida albicans is the etiologic agent. This is a serious infection found in congenital heart disease with or without surgery. It is potentially lethal, despite diagnostic and therapeutic advances. We report a case of infective endocarditis due to C. albicans after the treatment of a congenital systemic atrioventricular canal in a child with trisomy 21. The diagnosis was suspected on clinical manifestations and cardiac auscultation. Confirmation was provided by positive blood cultures and echocardiography. The large size of the vegetation in the patient was in favor of a fungal etiology, blood cultures allowed to identify the fungus. This observation illustrates a poorly understood disease, with very poor prognosis and which is a potential complication of heart surgery. The improved prognosis should be achieved by shortening the time to diagnosis and optimizing the therapeutic support.
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