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Published on: September 15, 2017
Interleukin-17 and acute coronary syndrome
Sheng-an Su1, Hong Ma, Li Shen
1Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Journal of Zhejiang University. Science. B
|July 31, 2013
Summary
Interleukin-17 (IL-17) shows a dual role in atherosclerosis and acute coronary syndrome (ACS). This review summarizes research on IL-17
Area of Science:
- Cardiovascular Science
- Immunology
- Molecular Biology
Background:
- Inflammation is a key factor in atherosclerosis and acute coronary syndrome (ACS).
- Interleukin-17 (IL-17), a pro-inflammatory cytokine, has emerged as a significant factor in cardiovascular disease.
- The precise role of IL-17 in ACS pathogenesis remains incompletely understood.
Purpose of the Study:
- To review and synthesize current experimental and clinical research on the role of IL-17 in atherosclerosis.
- To summarize the impact of IL-17 on atherosclerotic plaque stability and the onset of ACS.
- To elucidate the potential mechanisms underlying IL-17's dual function in ACS.
Main Methods:
- Comprehensive literature search of experimental and clinical studies.
- Analysis of research data on IL-17's effects on atherosclerotic plaques.
- Synthesis of findings regarding IL-17's association with ACS development and progression.
Main Results:
- IL-17 exhibits a complex, dual role in the progression of atherosclerosis and ACS.
- Evidence suggests IL-17 influences atherosclerotic plaque stability, though findings are sometimes contradictory.
- Research highlights varying effects of IL-17 depending on the specific context of ACS.
Conclusions:
- IL-17's involvement in ACS is significant but complex, with both pro- and anti-atherogenic effects observed.
- Further research is needed to clarify the precise mechanisms of IL-17 action in ACS.
- Understanding IL-17's role may offer novel therapeutic targets for managing atherosclerosis and ACS.
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