Related Experiment Videos

Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic

Zhen Sun1, Ying Shen, Lin Lu

  • 1Department of Cardiology, Shanghai Ruijin Hospital, Shanghai 200025, China.

Journal of Zhejiang University. Science. B
|July 31, 2013
PubMed

Insights

Reduced coronary collateral circulation in stable angina patients with chronic total occlusion is linked to clinical and angiographic factors like female gender, diabetes, and impaired renal function.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Internal Medicine

Background:

  • Coronary collateral circulation provides an alternative blood supply to the myocardium in advanced coronary artery disease.
  • Understanding factors influencing collateral development is crucial for managing patients with chronic total coronary occlusion.

Purpose of the Study:

  • To identify clinical and angiographic variables associated with coronary collateral development in patients with stable angina and chronic total coronary occlusion.

Main Methods:

  • Collected demographic, biochemical, and angiographic data from 478 patients with stable angina and chronic total coronary occlusion.
  • Assessed coronary collateralization using the Rentrop scoring system (0-3).

Main Results:

  • Nearly 40% of patients exhibited low coronary collateralization (Rentrop score 0-1).
  • Low collateralization was independently associated with older age (≥65 years), female gender, diabetes, no history of hypertension, dyslipidemia, moderate to severe renal dysfunction, single-vessel disease, and elevated high-sensitivity C-reactive protein (hsCRP).
  • Patients with low collateralization had higher rates of diabetes and dyslipidemia, and more impaired renal function compared to those with high collateralization.

Conclusions:

  • Coronary collateralization is reduced in a significant portion of stable angina patients with chronic total occlusion.
  • Clinical and angiographic factors play a key role in determining the extent of coronary collateralization.
  • Further research is needed to explore the impact of coronary collateralization on outcomes following revascularization.
Abstract

Related Concept Videos

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...