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Updated: May 9, 2026
A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
First total synthesis of the proposed structure of batatin VI
San-Yong Zhu1, Jia-Sheng Huang, Shan-Shan Zheng
1Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education, Department of Chemistry of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Abstract:
The first total synthesis of batatin VI, an architecturally novel resin glycoside dimer, has been achieved via a convergent [5 + 3] glycosidic coupling approach. An improved protocol for the construction of the key 18-membered macrolactone core using a Keck macrolactonization method was introduced. However, the synthesized compound was not identical to the natural batatin VI.
