Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of wheat-sensitive enteropathy in Irish Setters: morphologic changes.

E J Hall1, R M Batt

  • 1Department of Veterinary Pathology, University of Liverpool, England.

American Journal of Veterinary Research
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacokinetics of GS-441524 following intravenous remdesivir in six cats and results of therapeutic drug monitoring during treatment of feline infectious peritonitis: 22 cases (2021-2024).

The Journal of small animal practice·2025
Same author

Whole-Blood Taurine Concentrations in Cats With Intestinal Disease.

Journal of veterinary internal medicine·2017
Same author

Comparison of 3 Handling Techniques for Endoscopically Obtained Gastric and Duodenal Biopsy Specimens: A Prospective Study in Dogs and Cats.

Journal of veterinary internal medicine·2016
Same author

Campylobacter Species and Neutrophilic Inflammatory Bowel Disease in Cats.

Journal of veterinary internal medicine·2016
Same author

Bacterial Cholangitis, Cholecystitis, or both in Dogs.

Journal of veterinary internal medicine·2016
Same author

Does the Murphy's eye perform its role?

Anaesthesia·2015

Wheat sensitivity in Irish Setters causes intestinal damage. The study found that dietary wheat, not underlying issues, triggers morphologic changes like villus atrophy in affected dogs.

Area of Science:

  • Veterinary Medicine
  • Gastroenterology
  • Canine Health

Background:

  • Wheat-sensitive enteropathy is a condition affecting Irish Setters.
  • Understanding the morphologic changes and their causes is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the morphologic changes in the small intestine during the development of wheat-sensitive enteropathy in Irish Setters.
  • To differentiate between underlying abnormalities and secondary effects of intestinal damage caused by dietary wheat.

Main Methods:

  • Sequential peroral jejunal biopsies were collected from Irish Setters from 4 months to 1 year of age.
  • Affected dogs on a wheat-containing diet were compared to littermates on a cereal-free diet and to healthy controls on a wheat-containing diet.

Related Experiment Videos

Main Results:

  • At 4 months, affected dogs fed wheat showed increased intraepithelial lymphocytes and goblet cells, but no difference in villus height.
  • Dietary wheat led to progressive jejunal villus height reduction in affected dogs from 6 months onward.
  • No underlying morphologic abnormalities were identified; changes were secondary to dietary wheat.

Conclusions:

  • The characteristic morphologic changes in canine wheat-sensitive enteropathy are secondary to dietary wheat exposure.
  • Increased intraepithelial lymphocytes and goblet cells precede the development of partial villus atrophy.