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Related Concept Videos

Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's criteria,...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Pleural Effusion II: Symptoms and Management01:28

Pleural Effusion II: Symptoms and Management

Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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Related Experiment Video

Updated: May 9, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Primary effusion lymphoma.

Sanjay Patel1, Philip Xiao

  • 1Department of Pathology and Laboratory Medicine, The Brooklyn Hospital Center, Brooklyn, New York 11201, USA.

Archives of Pathology & Laboratory Medicine
|August 1, 2013
PubMed
Summary
This summary is machine-generated.

Primary effusion lymphoma (PEL) is a rare non-Hodgkin lymphoma found in body cavities, often linked to human herpesvirus 8 in immunocompromised patients. Diagnosis requires identifying HHV-8 latent antigens, and treatment options remain limited.

Related Experiment Videos

Last Updated: May 9, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

  • Oncology
  • Virology
  • Pathology

Background:

  • Primary effusion lymphoma (PEL) is a distinct aggressive non-Hodgkin lymphoma.
  • PEL predominantly affects body cavities, such as pleural, peritoneal, and pericardial spaces.
  • It is strongly associated with human herpesvirus 8 (HHV-8) infection.

Purpose of the Study:

  • To review the clinicopathologic features of primary effusion lymphoma.
  • To highlight diagnostic criteria and current treatment limitations for PEL.
  • To consolidate information on this rare lymphoid malignancy.

Main Methods:

  • Review of existing literature on primary effusion lymphoma.
  • Analysis of clinicopathologic characteristics from case studies and reviews.
  • Focus on histological findings and etiological associations, particularly HHV-8.

Main Results:

  • PEL presents as lymphomatous effusions without solid tumor masses.
  • Histologically, it shows large B-cell lymphoid cells with specific nuclear features.
  • Diagnosis is confirmed by detecting HHV-8 latent antigens.

Conclusions:

  • Primary effusion lymphoma is a unique entity requiring specific diagnostic approaches.
  • The association with HHV-8 in immunocompromised individuals is a key characteristic.
  • Further research is needed to improve therapeutic strategies for PEL.