Related Experiment Video
Updated: May 9, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
[Amyloid aggregates: role in Protein Misfolding Disorders]
Claudia Duran-Aniotz1, Inés Moreno-Gonzalez, Rodrigo Morales
1Mitchell Center for Alzheimer's disease and related Brain Disorders, Department of Neurology, University of Texas Medical School at Houston, Houston, Texas 77030, USA.
Abstract:
Misfolding and aggregation of proteins are the main features of a group of diseases termed Protein Misfolding Disorders (PMDs). PMDs include Alzheimer's disease and Transmissible Spongiform Encephalopathies, among many others. The deposition of protein aggregates is the main responsible for tissue damage and the consequent clinical signs generated in such disorders. In this review, we will focus in the role of protein aggregates in these diseases and in the putative mechanisms by which they exert their toxicity.
Related Concept Videos
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Alzheimer Disease ll: Pathophysiology
Protein Folding
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Folding
Parkinson Disease ll: Pathophysiology

