Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...

Drugs for Treatment of Ulcerative Colitis in IBD

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

JiangyaTongluo decoction ameliorates tubulointerstitial fibrosis via regulating the SIRT1/PGC-1α/mitophagy axis in hypertensive nephropathy.

Frontiers in pharmacology·2024

Same author

Enhancing Magnetic Hyperthermia Efficiency in Pd/Fe-Oxide Hybrid Nanoparticles through Mn-Doping.

ACS applied nano materials·2024

Same author

Direct endovascular treatment may be more appropriate for patients with good collateral circulation: a retrospective case-control study.

Quantitative imaging in medicine and surgery·2024

Same author

Improved CSW-YOLO Model for Bitter Melon Phenotype Detection.

Plants (Basel, Switzerland)·2024

Same author

Synthesis, Structure, and Properties of 2D Lanthanide(III) Coordination Polymers Constructed from Cyclotriphosphazene-Functionlized Hexacarboxylate Ligand.

Molecules (Basel, Switzerland)·2024

Same author

Cell membrane-camouflaged nanoparticles activate fibroblast-myofibroblast transition to promote skin wound healing.

Biofabrication·2024

Search research articles

Related Experiment Videos

UP446, analgesic and anti-inflammatory botanical composition.

Mesfin Yimam¹, Lidia Brownell, Mandee Pantier

¹Unigen Inc., Seattle, Washington, USA.

Pharmacognosy Research

|August 1, 2013

Summary

UP446, a botanical composition, significantly reduced pain and swelling in a rat model of rheumatoid arthritis (RA). These findings suggest UP446 as a potential alternative therapy for RA patients.

Keywords:

Acacia catechu Scutellaria baicalensis Georgi inflammation pain rheumatoid arthritis

Related Experiment Videos

Area of Science:

Pharmacology
Immunology
Natural Products

Background:

Rheumatoid arthritis (RA) is a chronic autoimmune disease requiring safe, long-term treatment options.
Current RA therapies have adverse effects limiting their use.
UP446, derived from Scutellaria baicalensis and Acacia catechu, targets inflammatory pathways.

Purpose of the Study:

To assess UP446's efficacy in an experimental rat model of RA.
To evaluate UP446's impact on arthritis-related symptoms.

Main Methods:

A rat model of RA was established using Freund's complete adjuvant.
Animals received UP446 (50 mg/kg), ibuprofen (150 mg/kg), or vehicle orally for 14 days.
Pain sensitivity and paw edema were measured.

Main Results:

UP446 treatment led to significant reductions in pain sensitivity (up to 33.4%) and ankle diameter (up to 46.0%).
Paw edema was notably reduced by an average of 30% during the initial inflammatory phase and up to 37.1% later.
UP446 demonstrated comparable or superior effects to ibuprofen in reducing RA symptoms.

Conclusions:

UP446 shows potential in alleviating RA symptoms.
The botanical composition UP446 warrants further clinical investigation for RA treatment.