Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Redox Reactions

Redox Reactions

Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...

Redox Reactions

Redox Reactions

Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...

Redox Equilibria: Overview

Redox Equilibria: Overview

A reduction-oxidation reaction is commonly called a redox reaction. In a redox reaction, electrons are transferred from one species to another rather than being shared between or among atoms. The reducing agent or reductant is the species that loses electrons and gets oxidized in the process. The species that gains electrons and gets reduced in the process is the oxidizing agent or oxidant. Redox reactions are represented as two separate equations called half-reactions, where one equation...

RC Circuit without Source

RC Circuit without Source

When a DC source is abruptly disconnected from an RC (Resistor-Capacitor) circuit, the circuit becomes source-free. Assuming that the capacitor was fully charged before the source was removed, its initial voltage, denoted as V0, can be considered as the initial energy that stimulates the circuit.
Applying Kirchhoff's current law at the top node of the circuit and substituting the current values across the components, a first-order differential equation is obtained. By rearranging the terms in...

RC Circuit with Source

RC Circuit with Source

When a DC source is abruptly applied to an RC (Resistor-Capacitor) circuit, the voltage can be represented as a unit step function. The voltage across the capacitor, known as the step response, characterizes how the circuit reacts to this sudden change in input.
Due to the inherent properties of a capacitor, its voltage cannot change instantaneously. This means that immediately after the switch is closed, the capacitor's voltage remains the same as it was just before the switch was closed.
By...

Electron Transport Chain: Complex III and IV

Electron Transport Chain: Complex III and IV

During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: The receptor for urokinaseplasminogen activator uPAR controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style.

Oncotarget·2026

Same author

Non-Enzymatic Isolation of Cancer-Associated Fibroblasts From Human Prostate Tumor Explants.

Bio-protocol·2026

Same author

Targeting carbonic anhydrase IX/XII prevents the anti-ferroptotic effect of stromal lactic acid in prostate carcinoma.

Molecular oncology·2025

Same author

Setup of an In Vitro Three-Dimensional Stromalized Prostate Cancer Model Using Gelatin Microparticles.

ACS omega·2025

Same author

GPR55 senses lactate to sustain motility in prostate cancer cells.

Molecular and cellular biochemistry·2025

Same author

The role of protein lactylation: A kaleidoscopic post-translational modification in cancer.

Molecular cell·2025

Same journal

Inflammation Impairs Poststroke Recovery by Disrupting Iron Homeostasis in Brain.

Antioxidants & redox signaling·2026

Same journal

Histone Lactylation Links Glycolysis to Ferroptosis in Diabetic Cataract.

Antioxidants & redox signaling·2026

Same journal

Insights into the Multifaceted Roles of 3-Mercaptopyruvate Sulfurtransferase in Liver Diseases.

Antioxidants & redox signaling·2026

Same journal

NINJ1 Aggravates Doxorubicin-Induced Cardiotoxicity by Suppressing AMPK-Mediated HIF-1α Deubiquitination.

Antioxidants & redox signaling·2026

Same journal

<i>Corrigendum to:</i> Suppression of Cardiac Autophagy by Hyperinsulinemia in Insulin Receptor-Deficient Hearts Is Mediated by Insulin-Like Growth Factor Receptor Signaling.

Antioxidants & redox signaling·2026

Same journal

Sleeve Gastrectomy Is Associated with Improved Systemic Redox Homeostasis in T2DM Through Ghrelin-GHSR Attenuation, POMC Neuronal Modulation, and CD4<sup>+</sup> T Cell Metabolic Reprogramming.

Antioxidants & redox signaling·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 9, 2026

Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors

Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors

Published on: January 31, 2025

Redox circuitries driving Src regulation.

Elisa Giannoni¹, Paola Chiarugi

¹1 Department of Experimental and Clinical Biomedical Sciences, University of Florence , Florence, Italy .

Antioxidants & Redox Signaling

|August 2, 2013

Summary

This summary is machine-generated.

Src kinase, regulated by cysteine oxidation, plays a key role in cancer hallmarks like cell motility and survival. Understanding its redox control is crucial for developing new cancer therapies.

More Related Videos

EPR Monitored Redox Titration of the Cofactors of Saccharomyces cerevisiae Nar1

EPR Monitored Redox Titration of the Cofactors of Saccharomyces cerevisiae Nar1

Published on: November 26, 2014

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation

Published on: February 27, 2019

Related Experiment Videos

Last Updated: May 9, 2026

Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors

Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors

Published on: January 31, 2025

EPR Monitored Redox Titration of the Cofactors of Saccharomyces cerevisiae Nar1

EPR Monitored Redox Titration of the Cofactors of Saccharomyces cerevisiae Nar1

Published on: November 26, 2014

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation

Published on: February 27, 2019

Area of Science:

Biochemistry and Molecular Biology
Cancer Biology
Cell Signaling

Background:

Src kinase activity is regulated by phosphorylation and cysteine oxidation.
Redox regulation of Src kinase is implicated in cell signaling, motility, and cancer progression.
Src kinase controls NADPH oxidase, influencing invadopodia formation and metastasis.

Purpose of the Study:

To review recent advances in the role of Src kinase in cancer biology.
To highlight the significance of redox circuitries in Src kinase regulation.
To discuss the implications for cancer hallmarks and therapeutic strategies.

Main Methods:

Literature review of recent studies on Src kinase and redox biology.
Analysis of Src kinase's role in cytoskeleton organization, cell adhesion, and motility.
Focus on redox-dependent mechanisms and their link to cancer hallmarks.

Main Results:

Src kinase's involvement in cytoskeleton organization, cell adhesion, and motility is modulated by redox mechanisms.
Redox regulation of Src kinase is crucial for cell survival, anoikis resistance, and metabolic deregulation.
Src kinase acts as an upstream regulator of oxidants, critical for metastasis.

Conclusions:

Further research is needed to clarify the hierarchy of oxidants, Src redox activation, and cell motility regulation.
Investigating the susceptibility of cancer cells to redox-based treatments is essential.
Redox circuitries involving Src kinase offer potential biomarkers and therapeutic targets for cancer and fibrotic diseases.