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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
[Meningococcus B vaccine: a new tool against invasive bacteric diseases]
Cristiana Carlino1, Laura Zaratti, Elisabetta Franco
1Scuola di Specializzazione in Igiene e Medicina Preventiva, Università di Roma Tor Vergata.
Abstract:
After the introduction of the conjugate vaccine against meningococcus C, serogroup B became the main agent of meningococcal disease in Europe. A new approach called "reverse vaccinology" was applied to identify new antigenic proteins able to induce the production of bactericidal antibodies. The final formulation of the vaccine against serogroup B contains three antigens and the outer membrane vesicles derived from MenZB vaccine used in New Zealand. The vaccine has proved to be highly immunogenic against a wide range of meningococcus B strains in all age groups.
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