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Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Asthma-IV: Nursing Management

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
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Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

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Updated: May 9, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Symptom-based controller therapy: a new paradigm for asthma management.

Rohit Divekar¹, Bill T Ameredes, William J Calhoun

¹Division of Allergy and Clinical Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA.

Current Allergy and Asthma Reports

|August 2, 2013

Summary

Daily controller medication for persistent asthma may not be necessary. A symptom-based approach using inhaled corticosteroids (ICS) intermittently can achieve similar outcomes with reduced exposure, benefiting selected asthma patients.

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Published on: November 4, 2010

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion

Published on: May 12, 2023

Area of Science:

Pulmonology
Allergy and Immunology
Clinical Medicine

Background:

Current persistent asthma management guidelines recommend daily controller medications, primarily inhaled corticosteroids (ICS).
Daily ICS use, while effective, presents treatment burdens and potential side effects for patients.
Alternative management strategies are being explored to optimize asthma care.

Purpose of the Study:

To evaluate the efficacy and safety of an intermittent, symptom-based approach to inhaled corticosteroid (ICS) therapy for persistent asthma.
To determine if this approach yields equivalent outcomes to daily ICS use in selected patients.
To explore the concept of 'temporal personalization' in asthma management.

Main Methods:

Review of large, randomized, controlled studies across various asthma severities and age groups (pediatric to adult).
Comparison of outcomes between patients using ICS based on symptoms versus daily ICS regimens.
Analysis of data to assess treatment effectiveness and ICS exposure.

Main Results:

Symptom-based intermittent ICS therapy demonstrated equivalent outcomes to daily ICS in well-selected asthma patients.
This approach significantly reduces overall patient exposure to inhaled corticosteroids.
The strategy is applicable across a range of asthma severities and patient ages.

Conclusions:

Intermittent, symptom-based controller therapy is a viable alternative to daily ICS for selected persistent asthma patients.
This approach offers comparable efficacy while minimizing ICS-related burdens and side effects.
Temporal personalization through symptom-based ICS could be integrated into future asthma management guidelines.