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Updated: May 9, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Migraine and neurogenetic disorders.
1Saint Joseph's Regional Medical Center, 703 Main Street, X618, Paterson, NJ 07503, USA. sathes@sjhmc.org
Current Pain and Headache Reports
|August 2, 2013
Summary
Genetic disorders causing headaches are currently misclassified. This review suggests a new category for migraine related to genetic disorders, highlighting their shared pathways and clinical features.
Area of Science:
- Neurology
- Genetics
- Vascular Biology
Background:
- Current headache disorder classifications do not independently categorize headaches linked to genetic disorders.
- These headaches are often subsumed under cranial or cervical vascular disorders, implying a vascular pathology as the sole cause.
- Migraine is a frequent symptom in several genetic cerebral small vessel diseases.
Observation:
- Genetic cerebral small vessel diseases like CADASIL and RVCL present with prominent migraine features.
- Shared genetic underpinnings and vascular endothelial dysfunction are potential contributors to migraine pathogenesis in these conditions.
- Overlapping genetic pathways may elucidate the comorbidity between genetic vasculopathies and migraine.
Findings:
- This review examines the clinical characteristics of genetic vasculopathies.
- Evidence suggests a strong link between specific genetic disorders and migraine.
- Pathophysiological mechanisms underlying the comorbidity require further investigation.
Implications:
- A distinct classification for 'migraine related to genetic disorders' is proposed.
- This new category could improve diagnostic accuracy and research focus.
- Understanding shared genetic and molecular pathways may lead to novel therapeutic targets.
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