Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

INDEPENDENT AND COMBINED EFFECTS OF HYPERGLYCEMIA AND CHRONIC KIDNEY DISEASE ON BONE MINERAL DENSITY AND MICROARCHITECTURE.

Acta endocrinologica (Bucharest, Romania : 2005)·2026
Same author

THE INDEPENDENT EFFECTS OF TYPE 2 DIABETES MELLITUS AND CHRONIC KIDNEY DISEASE ON BONE TURNOVER MARKERS.

Acta endocrinologica (Bucharest, Romania : 2005)·2024
Same author

Treatment of Obesity with Thyroid hormones in Europe. Data from the THESIS* Collaboration.

Journal of endocrinological investigation·2024
Same author

INSULIN RESISTANCE AND PATHOGENESIS OF POSTMENOPAUSAL OSTEOPOROSIS.

Acta endocrinologica (Bucharest, Romania : 2005)·2024
Same author

THE LEARNING CURVE AND PERFORMANCE OF A NEWLY ESTABLISHED THYROID FINE-NEEDLE ASPIRATION CENTER.

Acta endocrinologica (Bucharest, Romania : 2005)·2023
Same author

Cost-effectiveness and cost-utility of add-on, low-dose prednisolone in patients with rheumatoid arthritis aged 65+: The pragmatic, multicenter, placebo-controlled GLORIA trial.

Seminars in arthritis and rheumatism·2022

Related Experiment Video

Updated: May 9, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

The serotonin and the bone assessment.

M Carsote1, V Radoi, A Geleriu

  • 1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. carsote_m@hotmail.com

Journal of Medicine and Life
|August 2, 2013
PubMed
Summary

Serum serotonin shows inconsistent correlations with bone turnover markers and bone mineral density in postmenopausal women. Further research is needed to clarify its role in skeletal health evaluation.

Keywords:
Alkaline PhosphataseCrossLapsOsteocalcinosteoporosisserotonin

More Related Videos

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Related Experiment Videos

Last Updated: May 9, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Clinical Biochemistry

Background:

  • Emerging evidence suggests serotonin metabolism influences bone health.
  • Current clinical guidelines lack recommendations for serum serotonin assessment in evaluating skeletal status.

Purpose of the Study:

  • To investigate the correlation between serum serotonin levels and bone turnover markers (serum alkaline phosphatase, serum osteocalcin, serum CrossLaps) and lumbar bone mineral density (BMD) in postmenopausal women.

Main Methods:

  • Cross-sectional study involving 191 Caucasian postmenopausal women without carcinoid syndrome or bone anomalies.
  • Assessed serum serotonin via high-pressure liquid chromatography.
  • Measured bone formation markers (serum alkaline phosphatase, serum osteocalcin) and bone resorption marker (serum CrossLaps).
  • Determined lumbar bone mineral density (BMD) using central DXA.

Main Results:

  • Serum serotonin showed a statistically significant correlation with serum osteocalcin in the newly diagnosed osteoporosis group (N=40).
  • A statistically significant correlation was found between serum serotonin and serum alkaline phosphatase in the osteopenia group (N=88).
  • No statistically significant correlation was observed between serum serotonin and serum CrossLaps or lumbar bone mineral density.

Conclusions:

  • The findings suggest inconsistent correlations between serum serotonin and bone health indicators, questioning its utility as a sole marker for bone metabolism.
  • The study highlights the need for further investigation, particularly considering potential confounding factors like antidepressant use.
  • This pilot study underscores the unclear role of serum serotonin in current skeletal evaluation, necessitating more research in clinical practice.