Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alcohol consumption, substance use disorder and COVID-19.

European review for medical and pharmacological sciences·2022
Same author

Commentary: Metabolic associated liver disease: an inevitable terminological evolution in real practice.

European review for medical and pharmacological sciences·2022
Same author

Identification of harmful drinking in subjects who have had their driving license suspended due to alcohol use: a retrospective Italian study.

European review for medical and pharmacological sciences·2020
Same author

The undertreatment of alcohol-related liver diseases among people with alcohol use disorder.

European review for medical and pharmacological sciences·2020
Same author

Chemoprevention of hepatocellular carcinoma in people affected by hepatitis C virus: what changes does the introduction of direct-acting antiviral agents make?

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Alcohol and disease prevention.

Diabetes & metabolism·2015
Same journal

Healthcare costs of COVID-19 hospitalization in maintenance hemodialysis patients during the first two pandemic waves in Romania: a retrospective cohort study.

Journal of medicine and life·2026
Same journal

Clinical and inflammatory biomarkers predicting emergency surgical management decisions and postoperative outcomes in complicated colon cancer.

Journal of medicine and life·2026
Same journal

Antibiotic stewardship and safety in office-based transrectal prostate biopsy: a single-center retrospective analysis of complications.

Journal of medicine and life·2026
Same journal

Epigenetic mechanisms in preeclampsia: translational therapeutic strategies and precision-medicine perspectives.

Journal of medicine and life·2026
Same journal

Short-term functional outcome and pain assessment after spinal decompression for spondylodiscitis.

Journal of medicine and life·2026
Same journal

Effects of vitamin K administration on liver function, inflammation, and coagulation in chronic viral hepatitis: a retrospective study.

Journal of medicine and life·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

Alcoholic hepatitis.

G Testino1

  • 1Centro Alcologico Regionale - Regione Liguria, Alcohol Unit, Department of Internal and Specialist Medicine, IRCCS AOU San Martino-National Institute for Cancer research, Genova, Italy. gianni.testino@hsanmartino.it

Journal of Medicine and Life
|August 2, 2013
PubMed
Summary
This summary is machine-generated.

Severe alcoholic hepatitis (AH) has a poor prognosis. For eligible patients, liver transplantation (LT) should be considered even without the standard 6-month alcohol abstinence period.

Keywords:
Alcoholic HepatitisAlcoholic Liver DiseaseLiver Transplantation

More Related Videos

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Related Experiment Videos

Last Updated: May 9, 2026

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Area of Science:

  • Hepatology
  • Gastroenterology
  • Transplantation Medicine

Background:

  • Alcoholic hepatitis (AH) is a severe liver condition linked to prolonged alcohol misuse.
  • Severe acute AH (AAH) carries a high mortality rate (40-60% within six months).
  • Current treatments include glucocorticoids for patients with Maddrey's Discriminant Function score > 32.

Purpose of the Study:

  • To evaluate the role of liver transplantation (LT) in severe alcoholic hepatitis (AH).
  • To challenge the strict 6-month abstinence requirement for LT in eligible severe AAH patients.
  • To improve survival rates for patients with severe AAH who do not respond to initial therapies.

Main Methods:

  • Review of current treatment guidelines for severe alcoholic hepatitis.
  • Analysis of prognostic factors and outcomes for patients with severe AAH.
  • Discussion of contraindications and eligibility criteria for liver transplantation in AH.

Main Results:

  • Severe AAH patients often have a poor prognosis, with high short-term mortality.
  • Glucocorticoids are standard treatment, but many patients do not respond.
  • Liver transplantation is an option for non-responders, but the 6-month abstinence rule limits its use.

Conclusions:

  • The mandatory 6-month pre-transplant abstinence period for liver transplantation in severe AH may be too restrictive.
  • For carefully selected severe AAH patients with adequate social support and no psychiatric issues, LT should be considered without this waiting period.
  • Revising LT criteria could save lives in this high-risk patient population.