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Updated: May 9, 2026
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Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
Published on: August 12, 2018
[Deep brain stimulation. New target areas and new indications]
M M Reich1, A A Kühn, J Volkmann
1Neurologische Klinik und Poliklinik, Universitätsklinik Würzburg, Würzburg, Deutschland.
Der Nervenarzt
|August 3, 2013
Summary
Deep brain stimulation (DBS) offers new hope for neurological and psychiatric disorders when conventional treatments fail. This neuromodulation technique involves implanting electrodes to improve motor and psychiatric symptoms, expanding therapeutic options.
Area of Science:
- Neurosurgery
- Neurology
- Psychiatry
Context:
- Conventional treatments are insufficient for many neurological movement and psychiatric disorders.
- Deep brain stimulation (DBS) is an established therapeutic option.
- Over 100,000 patients worldwide had received DBS by 2012.
Purpose:
- To provide an overview of the latest developments in DBS.
- To explore established and emerging applications of DBS.
- To highlight advancements in neuromodulation for neurological and psychiatric diseases.
Summary:
- Deep brain stimulation (DBS) involves implanting electrodes in subcortical brain areas for high-frequency stimulation.
- Established indications include Parkinson's syndrome, dystonia, and tremors.
- Emerging indications, currently ~5% of cases, include depression, obsessive-compulsive disorder, addiction, and Tourette syndrome.
Impact:
- DBS offers an extended therapeutic option for patients with limited conventional treatment success.
- Advancements in understanding disease physiology drive the search for new DBS targets and indications.
- This review covers the evolving landscape of DBS applications in both established and developing areas.
