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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Immunodeficiency Diseases01:25

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Related Experiment Video

Updated: Feb 17, 2026

Murine Bilateral Renal Lymphadenectomy
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Everything is autoimmune until proven otherwise.

Yehuda Shoenfeld1

  • 1Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, shoenfel@post.tau.ac.il.

Clinical Reviews in Allergy & Immunology
|August 3, 2013
PubMed
Summary

The study highlights the underrepresentation of immunology in physiology textbooks despite its crucial role in internal medicine and disease. It emphasizes that autoimmunity is a complex field with more autoantibodies than diseases, many of which are rare.

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Area of Science:

  • Immunology and Autoimmunity
  • Internal Medicine
  • Serology and Cellular Immune Response

Background:

  • Immunology is often overlooked in physiology education but is integral to internal medicine.
  • Historical understanding of immune response evolved from allergy to infection control and autoimmunity.
  • Autoimmunity is a relatively new concept, gaining depth with advancements in serology and cellular immunity.

Discussion:

  • The prevalence of autoantibodies significantly exceeds the number of identified autoimmune diseases.
  • Autoimmune diseases are more numerous than previously recognized, with a growing understanding since 1963.
  • Many autoimmune conditions are classified as orphan diseases, posing challenges for pharmaceutical development.

Key Insights:

  • A vast number of autoantibodies exist, but only a fraction are linked to specific autoimmune diseases.
  • The recognition and classification of autoimmune diseases have expanded considerably over time.
  • The financial viability of developing treatments for rare autoimmune diseases is often limited.

Outlook:

  • Future research should explore the link between the innate and adaptive immune responses and various inflammatory conditions.
  • A paradigm shift is needed, considering all diseases as potentially autoimmune until proven otherwise.
  • Continued investigation into less-discussed aspects of autoimmunity is crucial for advancing the field.