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Left ventricular diastolic dysfunction -- early cardiac impairment in patients with polymyositis/dermatomyositis: a

Zhang Lu1, Qiao Wei, Zu Ning

  • 1Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China.

The Journal of Rheumatology
|August 3, 2013
PubMed
Abstract

Insights

Tissue Doppler imaging (TDI) detects early cardiac impairment in polymyositis/dermatomyositis (PM/DM) patients. Female sex, late onset, and disease duration are key risk factors for diastolic dysfunction.

Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Polymyositis/dermatomyositis (PM/DM) are inflammatory myopathies that can affect the heart.
  • Early detection of cardiac involvement is crucial for managing PM/DM patients.

Purpose of the Study:

  • To investigate early cardiac involvement in patients with PM/DM.
  • To identify risk factors for early cardiac impairment in this population.

Main Methods:

  • 46 PM/DM patients without overt cardiovascular disease and 21 healthy controls were studied.
  • Traditional echocardiography and tissue Doppler imaging (TDI) were used to assess cardiac function.
  • Multivariate logistic regression identified risk factors for cardiac impairment.

Main Results:

  • TDI revealed significantly impaired diastolic function (lower Em/Am, higher E/Em) in PM/DM patients compared to controls.
  • Traditional echocardiography showed no significant differences.
  • Female sex, late onset, and longer disease duration were independent risk factors for abnormal left ventricular filling pressures.

Conclusions:

  • TDI is a sensitive tool for detecting subclinical cardiac involvement in PM/DM.
  • Left ventricular diastolic dysfunction is an early manifestation of cardiac involvement in PM/DM.
  • Female sex, late onset, and disease duration predict diastolic dysfunction in PM/DM patients.
Keywords:
DERMATOMYOSITISLEFT VENTRICULAR DIASTOLIC DYSFUNCTIONPOLYMYOSITISTISSUE DOPPLER ECHOCARDIOGRAPHY

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