Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Microbiome of the Eye

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chronic Diabetic Tractional Retinal Detachment and Poor Visual Acuity: Should We Be Performing Surgery on These Patients?

Journal of vitreoretinal diseases·2025

Same author

Panretinal photocoagulation during vitrectomy for diabetic vitreous hemorrhage: A clinical trial comparing endolaser application amounts.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)·2025

Same author

Real-World Outcomes with Complement Inhibitors for Geographic Atrophy: A Comparative Study of Pegacetacoplan versus Avacincaptad Pegol.

Clinical ophthalmology (Auckland, N.Z.)·2025

Same author

One-Year Outcomes in Subjects Developing Macular Neovascularization While Undergoing Avacincaptad Pegol Therapy for Geographic Atrophy.

Clinical ophthalmology (Auckland, N.Z.)·2025

Same author

Real-World Outcomes in Pre-Existing Neovascular Age-Related Macular Degeneration Subjects Undergoing Avacincaptad Therapy for Geographic Atrophy.

Clinical ophthalmology (Auckland, N.Z.)·2025

Same author

Long-Standing Macula-Involving Diabetic Tractional Retinal Detachments with Good Visual Acuity: How Should We Manage These Patients?

Clinical ophthalmology (Auckland, N.Z.)·2024

Search research articles

Related Experiment Video

Updated: May 9, 2026

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

Contact lens-associated nocardial necrotizing scleritis.

¹Southwest Retina Specialists, Amarillo, TX 79106, USA. Ryanbradfordrush21@hotmail.com

Korean Journal of Ophthalmology : KJO

|August 3, 2013

Summary

Nocardia asteroides complex caused severe necrotizing scleritis in a contact lens wearer. Prompt treatment with antibiotics successfully resolved the infection, restoring vision.

Area of Science:

Ophthalmology
Infectious Diseases

Background:

Necrotizing scleritis is a severe inflammatory condition of the eye's sclera.
It can be associated with autoimmune diseases or infections.
Contact lens wear is a known risk factor for ocular infections.

Observation:

A 52-year-old male contact lens wearer presented with a month of progressive right eye pain and redness.
Previous evaluations for autoimmune and infectious causes were inconclusive.
Ocular examination revealed necrotizing scleritis without keratitis.

Findings:

Scleral culture identified heavy growth of Nocardia asteroides complex.
The patient was treated with topical amikacin and oral trimethoprim-sulfamethoxazole (Bactrim).
Complete resolution of the infection and return to baseline visual acuity were achieved after several weeks of treatment.

Keywords:

Contact lenses Scleritis

More Related Videos

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients

Published on: August 2, 2024

Related Experiment Videos

Last Updated: May 9, 2026

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients

Published on: August 2, 2024

Implications:

Nocardia asteroides complex is a rare but serious cause of necrotizing scleritis.
Contact lens wearers are at risk, even without concurrent keratitis.
Early diagnosis and appropriate antimicrobial therapy are crucial for favorable outcomes in Nocardia scleritis.