Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Ethical Issues01:27

Ethical Issues

Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
Ethics and Bioethics01:22

Ethics and Bioethics

Ethics is a philosophical study of moral actions. Ethics attempts to determine what is valuable for individuals and society. It examines the rational justification of moral judgments and analyzes what is morally just, fair, and right. Bioethics is a sub-discipline of applied ethics that analyzes the philosophical, social, and legal issues in life sciences and medicine. Ethical theories serve as a foundation for decision-making and represent the viewpoints from which people seek direction. They...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Ethical Dilemmas I01:17

Ethical Dilemmas I

Ethical dilemmas in nursing are of utmost importance, as they often arise from the tension between adhering to core ethical principles and the practical realities of healthcare delivery. These dilemmas require nurses to navigate complex situations where competing ethical considerations pull them in different directions.
Let us explore some examples to understand the potentially complex moral decisions nurses face.
Take the case of caring for minors, particularly in areas related to reproductive...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Niclosamide: A potential antipruritic agent by modulating serotonin pathway through metabotropic glutamate receptors (mGluRs)".

Heliyon·2024
Same author

Additive Anticonvulsive Effects of Sumatriptan and Morphine on Pentylenetetrazole-Induced Clonic Seizures in Mice.

Journal of epilepsy research·2024
Same author

Spermidine Exerts Protective Effects in Random-Pattern Skin Flap Survival in Rats: Possible Involvement of Inflammatory Cytokines, Nitric Oxide, and VEGF.

Aesthetic plastic surgery·2024
Same author

Sex Dimorphism in Pain Threshold and Neuroinflammatory Response: The Protective Effect of Female Sexual Hormones on Behavior and Seizures in an Allergic Rhinitis Model.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology·2024
Same author

Cellular and molecular mechanisms involved in the analgesic effects of botulinum neurotoxin: A literature review.

Drug development research·2024
Same author

Sumatriptan mitigates bleomycin-induced lung fibrosis in male rats: Involvement of inflammation, oxidative stress and α-SMA.

Tissue & cell·2024
Same journal

Explicating the process of moral courage in clinical nurses: a grounded theory study.

Journal of medical ethics and history of medicine·2026
Same journal

Anti-epidemic campaigns in Macao during the war and post-war reconstruction period (1937 - 1949): a procedural grounded theory analysis of news reports from overseas Chinese news.

Journal of medical ethics and history of medicine·2026
Same journal

From ancient healing to modern litigation: a historical journey through medical negligence and tort law.

Journal of medical ethics and history of medicine·2026
Same journal

The need for tailored ethical guidelines in HIV/AIDS care.

Journal of medical ethics and history of medicine·2026
Same journal

From concept to practice: integrating ethical spirituality into philosophical counseling training.

Journal of medical ethics and history of medicine·2026
Same journal

Assessment of the medical professionalism climate in the inpatient units of a teaching hospital affiliated with Iran University of Medical Sciences (2023-2024).

Journal of medical ethics and history of medicine·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative
07:59

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

Ethical considerations in animal studies.

Mehdi Ghasemi1, Ahmad Reza Dehpour

  • 1Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran.

Journal of Medical Ethics and History of Medicine
|August 3, 2013
PubMed
Summary
This summary is machine-generated.

Ethical considerations are crucial in animal experimentation for biomedical research. This paper offers guidelines for researchers to ensure humane animal study designs, promoting responsible scientific practices.

Keywords:
Code of ethicsEthicsEthics in research

More Related Videos

Training Laboratory Rabbits to Refine Routine Husbandry Procedures
05:21

Training Laboratory Rabbits to Refine Routine Husbandry Procedures

Published on: February 16, 2024

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia
06:50

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia

Published on: March 20, 2018

Related Experiment Videos

Last Updated: May 9, 2026

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative
07:59

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

Training Laboratory Rabbits to Refine Routine Husbandry Procedures
05:21

Training Laboratory Rabbits to Refine Routine Husbandry Procedures

Published on: February 16, 2024

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia
06:50

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia

Published on: March 20, 2018

Area of Science:

  • Biomedical Research
  • Animal Ethics
  • Scientific Methodology

Background:

  • Millions of animals are used annually in scientific research, often undergoing distressing procedures.
  • Ethical considerations in animal experimentation are paramount in modern medical research.
  • Existing guidelines inform the development of ethical research practices.

Purpose of the Study:

  • To provide researchers with practical guidelines for ethical animal experimentation.
  • To support the design of studies that minimize animal distress.
  • To promote responsible conduct in biomedical research involving animals.

Main Methods:

  • Review and adaptation of existing ethical guidelines, specifically the American Association of Psychologists' Guidelines for Ethical Conduct in the Care and Use of Animals.
  • Development of a framework for researchers to apply in study design.
  • Focus on practical application for various animal models.

Main Results:

  • A set of actionable guidelines for ethical animal study design.
  • Emphasis on the importance of researcher responsibility and animal welfare.
  • Framework adaptable for diverse research settings.

Conclusions:

  • Adherence to ethical guidelines is essential for advancing biomedical research.
  • Implementing these guidelines can improve animal welfare in research settings.
  • Responsible animal experimentation is key to maintaining scientific integrity.