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Rewiring immunity: generating a functional thymus from hESCs… are we there yet?

Richard L Boyd1, Chew-Li Soh, Nicholas R Boyd

  • 1Department of Anatomy and Developmental Biology, Monash University, Clayton, 3800, Victoria, Australia. richard.boyd@monash.edu

Cell Stem Cell
|August 6, 2013
PubMed

Two papers in this issue of Cell Stem Cell have made a significant advance in solving one of the great challenges of modern immunology-resurrecting thymus function through the induction of thymus epithelial cells (TECs) by directed differentiation of human embryonic stem cells (hESCs).

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Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...