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Updated: May 9, 2026

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
Fatty infiltration of an aortic valve
Graham T Meredith1, Fabio Ramponi, James P Scurry
1Department of Cardiothoracic Surgery, John Hunter Hospital, New Lambton Heights, New South Wales, Australia. graham.meredith@hnehealth.nsw.gov.au
Abstract:
Adipose tissue is a normal constituent of the heart, but not a normal anatomic finding of cardiac valves. Fatty infiltration of the aortic valve is rare, with unknown significance on valve function. We report a case of fatty infiltration and replacement of the spongiosa layer in an incompetent aortic valve. The mechanism of fat infiltration is unknown, but may be explained by differentiation of preexisting valve interstitial cells secondary to valvular injury.
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