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Updated: May 9, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
¹³C cross-polarization magic-angle spinning nuclear magnetic resonance analysis of the solid drug forms with low
Dariusz Maciej Pisklak1, Monika Zielińska-Pisklak2, Lukasz Szeleszczuk1
1Faculty of Pharmacy, Medical University of Warsaw, Department of Physical Chemistry, Banacha 1, 02-093 Warsaw, Poland.
Abstract:
Solid State NMR is a method that could be widely used for analyzing solid state forms of drugs in their original formulations. However, when the concentration of the active pharmaceutical ingredient (API) in the final drug form is low, (13)C CP MAS NMR methods using standard parameters are not efficient. An example of this situation is propranolol, an important drug from the group of beta-blockers whose concentration in the final drug form is low (below 10%). Basing on the differences in the CP kinetics and relaxation parameters for propranolol and the excipients the authors suggest the proper set of the CP MAS experimental parameters that would allow one to analyze API even in small concentrations in the solid drug formulations.
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