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Updated: May 9, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase

Xiaoyu Tang1, Kornelia Eitel, Leonard Kaysser

  • 1Pharmaceutical Institute, University of Tübingen, Tübingen, Germany.

Nature Chemical Biology
|August 6, 2013
PubMed
Summary

Researchers discovered a novel two-step sulfation pathway in caprazamycin (CPZ) antibiotic biosynthesis. This process utilizes a unique type III polyketide synthase and two sulfotransferases to create essential sulfate donors for bacterial sulfate metabolism.

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