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Updated: May 9, 2026
03:32
A Pleural Effusion Model in Rats by Intratracheal Instillation of Polyacrylate/Nanosilica
Published on: April 12, 2019
Diagnostic exercise: ascites, abdominal masses, and diffuse peritoneal nodules in a rat
T K Cooper1, P R Dumpala, T L Whitcomb
1Department of Comparative Medicine, H054, Penn State Milton S. Hershey Medical Center, College of Medicine, 500 University Dr, Hershey, PA 17033, USA.
Veterinary Pathology
|August 6, 2013
Summary
A rare ovarian tumor in a fancy rat caused abdominal swelling and jaundice. The tumor featured pleomorphic cells and a unique, sugar-rich matrix.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
Background:
- Ovarian neoplasms are uncommon in rodents.
- Fancy rats can develop various tumors, necessitating detailed case studies.
Observation:
- A 1.4-year-old female fancy rat presented with abdominal distention, jaundice, and dyspnea.
- Physical examination revealed palpable abdominal masses and nodules on visceral surfaces.
- Necropsy confirmed a large ovarian mass and peritoneal tumor seeding with significant abdominal effusion.
Findings:
- Cytology of abdominal fluid showed pleomorphic, vacuolated tumor cells.
- These cells surrounded acellular material positive for periodic acid-Schiff (PAS) stain.
- Histology revealed a biphasic tumor with abundant PAS-positive hyaline matrix.
Implications:
- This case highlights a rare ovarian tumor in a fancy rat.
- The presence of a PAS-positive hyaline matrix is a distinctive feature.
- Further research may elucidate the specific cell of origin and tumor behavior.
