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Latanoprost-induced prostaglandin-associated periorbitopathy
1Nassau University Medical Center, East Meadow, Westbury, NY, USA.
Summary
Latanoprost eye drops can cause prostaglandin-associated periorbitopathy (PAP), a condition affecting the skin around the eyes. While less common than with other prostaglandins, awareness and monitoring are crucial for patients.
Area of Science:
- Ophthalmology
- Dermatology
Background:
- Prostaglandin analogs are widely used to treat glaucoma.
- Prostaglandin-associated periorbitopathy (PAP) is a known side effect of some prostaglandin analogs.
Observation:
- This study presents three cases of PAP induced by latanoprost.
- Patients exhibited involution of dermatochalasia, blepharoptosis, deepening of orbital sulci, and flattening of lower eyelid bags.
Findings:
- Latanoprost can cause PAP, characterized by specific periorbital changes.
- The onset of latanoprost-induced PAP appears to have a longer latency period compared to bimatoprost and travoprost.
Implications:
- Ophthalmologists should be aware of latanoprost-induced PAP and monitor patients for its development.
- Unilateral prostaglandin use may lead to noticeable asymmetry in the periorbital region, impacting aesthetics.
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