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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
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Infectious diseases in humanized mice.

Carol Leung1, Obinna Chijioke, Cornelia Gujer

  • 1Department of Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

European Journal of Immunology
|August 6, 2013
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Mice with human immune systems model human infections, offering insights into disease and immunity. These advanced models help predict patient responses to therapies and vaccines.

Keywords:
Dengue virusEBVHIVMycobacterium tuberculosisSalmonella enterica typhi

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Animal Models

Background:

  • Mice reconstituted with human immune system components successfully harbor diverse human leukocyte populations.
  • These humanized mouse models are utilized to study human-tropic pathogens like HIV, EBV, Mycobacterium tuberculosis, and Salmonella enterica Typhi.

Purpose of the Study:

  • To investigate the pathogenesis of human infections in vivo using humanized mouse models.
  • To gain functional insights into immune compartment protection and altered pathology in response to pathogen infections.
  • To advance the development of versatile small animal models for predicting human immune responses.

Main Methods:

  • Reconstitution of mice with human immune system components.
  • Infection of humanized mice with human-tropic pathogens (viruses and bacteria).
  • Analysis of immune responses, pathogenesis, and pathology in the context of humanized immunity.

Main Results:

  • Humanized mouse models recapitulate aspects of human immune responses to pathogens.
  • Studies revealed the protective value of specific immune compartments.
  • Mutant pathogen infections demonstrated altered pathology in these models.

Conclusions:

  • Humanized mouse models are valuable tools for studying human infectious diseases and immune responses in vivo.
  • Ongoing methodological advancements enhance the utility of these models for preclinical research.
  • These models show promise in predicting human immune responses to therapies and vaccines.