Related Experiment Video
Updated: May 9, 2026
In vivo Evaluation of Mucociliary Clearance in Mice
Published on: December 18, 2020
A respiratory correlated image guided surgery method: quantitative accuracy results in swine and human cadaver
Ryan L Smith1, Jie Wen, Camille Noel
1Amgen, Inc., Thousand Oaks, CA, 91320, USA.
Background:
Intervention on small targets in the lung is difficult, leading our team to develop a highly accurate respiratory correlated image guided surgery (RCIGS) system.
Methods:
Simulated point source targets were implanted into ex vivo porcine and human cadaver lungs attached to a ventilator. The RCIGS system was utilized to guide intervention in the presence of respiratory motion using a commercially available electromagnetic tracking solution. After intervention, the lungs were imaged to determine the target registration error between the target and needle.
Results:
The system tumor position modeling had sub-mm accuracy. The mean intervention error for 12 porcine targets was 3.8 mm. The mean target registration error on four targets in a human cadaver was 4.0 mm at a mean depth of 9 cm.
Conclusions:
The system provides an accuracy for intervention on targets of less than 1 cm in diameter at depths of up to 10 cm. A system of this accuracy outperforms current clinical standards.
