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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
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Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

MR parameter quantification with magnetization-prepared double echo steady-state (MP-DESS).

Tony Stöcker1, Fabian Keil, Kaveh Vahedipour

  • 1Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich, Juelich, Germany.

Magnetic Resonance in Medicine
|August 6, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a fast MRI method for simultaneous T1, T2, and M0 mapping. The novel technique achieves high accuracy and precision for quantitative imaging, aiding disease investigation.

Keywords:
double echo steady stateextended phase graphmagnetization preparationqMRI

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Area of Science:

  • Medical Imaging
  • Quantitative MRI

Background:

  • MR relaxation times (T1, T2) and proton density (M0) mapping are crucial for disease investigation.
  • Existing methods often lack speed or precision for simultaneous acquisition.

Purpose of the Study:

  • To develop a fast MRI protocol for simultaneous T1, T2, and M0 mapping.
  • To maintain accuracy and precision in quantitative parameter acquisition.

Main Methods:

  • A novel magnetization-prepared double echo steady-state (MP-DESS) sequence was designed.
  • The sequence offers high sensitivity to relaxation times and insensitivity to confounding variables.
  • Accurate phase graph modeling ensures unbiased parameter estimates.

Main Results:

  • Whole-brain imaging with 1.4-mm isotropic resolution was achieved in 15 minutes.
  • Mapping precision reached 5% for T1 and M0, and below 10% for T2.
  • Validation was confirmed through phantom and in vivo measurements.

Conclusions:

  • A new quantitative MRI technique enables rapid, simultaneous T1, T2, and M0 mapping.
  • This advancement facilitates efficient and precise medical imaging for disease research.