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[Radiation therapy for unresected gastric lymphoma]
M Kataoka1, M Kawamura, Y Kimura
1Department of Radiology, Ehime University School of Medicine.
Nihon Gan Chiryo Gakkai Shi
|May 20, 1990
Summary
Radiation therapy for unresected gastric lymphoma, often combined with chemotherapy (cyclophosphamide, adriamycin, vincristine, prednisone), shows high curability. This treatment approach is effective for locally advanced or stage IV disease without serious complications.
Area of Science:
- Oncology
- Radiation Oncology
Background:
- Review of six patients with unresected gastric lymphoma treated between 1976 and 1989.
- Focus on radiation therapy, often combined with chemotherapy.
Observation:
- Radiation therapy utilized involved fields with dosages ranging from 25.2 to 36 Gy (mean, 29.3 Gy).
- Most patients received chemotherapy combined with radiation, commonly the CHOP regimen.
- Three patients with locally invading tumors deemed unresectable received chemo-radiotherapy, with two surviving long-term (40 and 116 months).
Findings:
- Two of three patients diagnosed with clinical stage IV gastric lymphoma achieved long-term survival (21 and 66 months) after chemo-radiotherapy.
- Chemoradiotherapy demonstrated high curability for unresected, locally advanced, or stage IV gastric lymphomas.
Implications:
- Suggests chemoradiotherapy is a viable and effective treatment for unresected gastric lymphomas.
- Highlights the potential for high curability without significant complications in advanced gastric lymphoma cases.
- Supports the use of combined modality treatment in managing challenging gastric lymphoma presentations.