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An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
Paraganglioma of urinary bladder
Azhar Ali Malik1, Bachar Afandi, Gohar Jamil
1Division of Endocrinology, Tawam Hospital, Al-ain, Abu Dhabi, UAE. aamalik_06@yahoo.com
BMJ Case Reports
|August 7, 2013
Summary
Urinary bladder paraganglioma, a rare pheochromocytoma, can cause hypertensive crisis. Early diagnosis and management are crucial to prevent serious adverse outcomes from delayed recognition of this malignant neuroendocrine tumor.
Area of Science:
- Urology
- Endocrinology
- Oncology
Background:
- Paraganglioma of the urinary bladder is an exceptionally rare clinical diagnosis.
- Pheochromocytoma, a neuroendocrine tumor, can present with varied symptoms.
Observation:
- A young male patient experienced hypertensive crisis and ventricular arrhythmia during cystoscopic evaluation of a bladder mass.
- Elevated serum and urinary catecholamine levels initially suggested pheochromocytoma, but a meta-iodobenzylguanidine scan was negative.
- Post-surgical pathological examination confirmed extraadrenal pheochromocytoma.
Findings:
- Persistent elevation of catecholamine levels during follow-up was detected.
- Fluorodeoxyglucose positron emission tomography scan revealed abnormalities indicative of metastatic malignant neuroendocrine tumor.
- The patient was diagnosed with malignant paraganglioma and initiated on palliative chemotherapy.
Implications:
- This case underscores the diverse presentations of pheochromocytoma and the necessity of a high index of clinical suspicion for early diagnosis.
- Prompt management is vital, as delayed diagnosis of malignant paraganglioma can lead to severe adverse consequences.
- Highlights the importance of advanced imaging in identifying metastatic disease in neuroendocrine tumors.
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