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Related Experiment Video

Updated: May 9, 2026

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Published on: September 26, 2025

Analysing the skin barrier from down under.

J Grice¹, H A E Benson

¹Therapeutics Research Centre, School of Medicine, University of Queensland, Brisbane, Qld., Australia.

Skin Pharmacology and Physiology

|August 8, 2013

Summary

This summary is machine-generated.

Michael Roberts pioneered skin science in Australia, developing mathematical models for skin permeation and drug delivery. His work improved clinical outcomes and reduced toxicological risks.

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Area of Science:

Dermal and epidermal science
Pharmacokinetics and drug delivery
Toxicology and risk assessment

Background:

Michael Roberts' 40-year career has significantly advanced Australian skin science.
His early work in membrane permeation, published in Nature, laid the foundation for understanding skin permeability.
His research integrates fundamental science with practical applications in medicine and product safety.

Discussion:

Characterized by a mechanistic, mathematical approach, Roberts defined key skin permeation parameters and structure-penetration relationships.
He established the significance of maximum flux for clinical and toxicological assessments.
His work revealed a parabolic relationship between maximum flux and lipophilicity, driven by stratum corneum solubility.

Key Insights:

Roberts excels at translating complex biological concepts into mathematical models for epidermal, dermal, and follicular transport.
He pioneered technologies for skin barrier analysis and permeation modulation.
His fundamental research on iontophoresis provided models for enhanced drug permeation.

Outlook:

Roberts' research has directly led to improved clinical treatments and reduced toxicological risks.
His findings have influenced regulatory standards for skin products.
His legacy continues to shape the future of skin science and transdermal delivery.