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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
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Impact of Different Packaging Configurations on A Topical Cream Product
Yousuf H Mohammed1,2,3, S N Namjoshi4, K C Telaprolu4
1Therapeutics Research Centre, Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, Australia. y.mohammed@uq.edu.au.
Pharmaceutical Research
|September 30, 2024
Summary
Dispensing topical creams via a pump can alter their physicochemical properties and reduce active ingredient delivery compared to tube packaging. This impacts bioavailability and generic product testing.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Dermatology
Background:
- Topical creams are widely used for drug delivery.
- The packaging and dispensing method can influence product quality.
- Understanding these effects is crucial for consistent drug bioavailability.
Purpose of the Study:
- To determine if different dispensing methods (tube vs. pump) affect the physicochemical and structural attributes of a topical cream.
- To assess the impact of dispensing on the in vitro skin delivery performance of the cream.
Main Methods:
- Acyclovir cream was dispensed from tube and pump configurations.
- Structural attributes were analyzed using microscopy (optical, confocal Raman, cryo-SEM).
- Rheological behavior and in vitro permeation tests (IVPT) were performed.
Main Results:
- Dispensing via pump introduced dimethicone globules, altering cream structure.
- Rheological behavior differed significantly between pump-dispensed and tube-dispensed creams.
- Pump dispensing resulted in reduced rate and extent of acyclovir delivery through human epidermis.
Conclusions:
- Dispensing methods can induce structural changes (metamorphosis) in topical semisolid products.
- These changes can potentially alter the bioavailability of the active pharmaceutical ingredient.
- Findings are relevant for product development, manufacturing, and comparative testing of topical medications.
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